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Anti-TTR Protein A Scaffold (CAT#: AFB-40LY)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Transthyretin Protein A scaffold AFB-40LY 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • The Anti-Transthyretin Protein A Scaffold molecule was selected against human transthyretin. Cross reactivity with other species has not been tested. The Anti-Transthyretin Protein A Scaffold molecule is an ideal affinity ligand as capture reagent in ELISA and as capture molecule in affinity chromatography. The Anti-Transthyretin Protein A Scaffold molecule is modified with a unique C-terminal cysteine for directed single-point chemical modification, facilitating coupling to matrices.
  • Species Reactivity
  • human
  • Expression Host
  • E. coli
  • Applications
  • ELSIA
  • Specific Activity
  • Anti-Transthyretin Protein A scaffold molecule binds to human transthyretin. Cross reactivity with other species has not been tested.
  • Molecular Weight
  • 13.6 kDa
  • Storage
  • At +4°C is recommended for lyophilized protein. For reconstituted protein in physiological buffer, short-term storage at +4°C is recommended. For long-term storage, the protein solution should first be aliquoted and stored frozen at -20°C.
    There is no dec

BACKGROUND

  • Antigen Description
  • Transthyretin (TTR, Prealbumin) is synthesized by the liver as a 127 amino acid non-glycosylated polypeptide chain. The entity, circulating in plasma, is a structurally stable tetramer composed of four identical monomers. It was originally called pre-albumin, however it has no structural relationship with albumin. The main function of transthyretin is transport of thyroxin and retinol binding protein i.e. vitamin A. The transthyretin concentration in plasma ranges from 20-40 mg/ml and the level is decreased in subjects suffering from malnutrition or chronic inflammation. In hereditary transthyretin amyloidosis, mutated transthyretin causes aggregation and formation of amyloid deposits in tissues with peripheral neuropathy as the major clinical manifestation.
  • Function
  • hormone activity; hormone binding; protein binding
  • Synonyms
  • TTR; transthyretin; CTS; CTS1; PALB; TBPA; HsT2651; prealbumin, amyloidosis type I; Transthyretin; ATTR; Prealbumin; OTTHUMP00000162827; carpal tunnel syndrome 1; thyroxine-binding prealbumin

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